小堀　哲生　

プロフィール

取得学位

• 修士（理学）, 東京工業大学, 1999年03月
• 博士（理学）, 東京工業大学, 2002年03月

職歴（学外）

職歴（学内）

研究室ホームページ

『研究室ホームページへのリンク』

教育活動

担当授業

• 生化学Ⅲ
• 機能分子化学Ⅰ
• 生体制御分子設計
• 生体分子設計学

シラバス

研究活動

研究分野

• 研究分野:生物有機化学, 生体化学
• 知のシーズ:『知のシーズ集システムへのリンク』

論文

• Development of 7SK snRNA mimics that inhibit HIV transcription.
  著者名 : Asako Yamayoshi; Hiroyuki Fukumoto; Rie Hayashi; Kyosuke Kishimoto; Akio Kobori; Yoshio Koyanagi; Jun A Komano; Akira Murakami
  掲載誌名 : ChemMedChem
  出版年月 : 2021年07月
• Ratiometric SERS Assays for Reliable and Automatic Quantification of Nucleic Acids
  著者名 : Ryo Ota; Yuki Fukushima; Yuta Araki; Kenta Sasaki; Tomonori Waku; Akio Kobori
  掲載誌名 : CHEMISTRY LETTERS
  出版年月 : 2021年03月
• Investigation on the Interactions between Self-Assembled beta-Sheet Peptide Nanofibers and Model Cell Membranes
  著者名 : Tomonori Waku; Ayane Kasai; Akio Kobori; Naoki Tanaka
  掲載誌名 : INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  出版年月 : 2020年12月
• Sandwich-type detection of nucleic acids by bioorthogonal SERS probes
  著者名 : Ryo Ota; Noriyuki Takagi; Yu Imaizumi; Tomonori Waku; Akio Kobori
  掲載誌名 : NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
  出版年月 : 2020年11月
• Development of Antibody-Oligonucleotide Complexes for Targeting Exosomal MicroRNA
  著者名 : Asako Yamayoshi; Shota Oyama; Yusuke Kishimoto; Ryo Konishi; Tsuyoshi Yamamoto; Akio Kobori; Hiroshi Harada; Eishi Ashihara; Hiroshi Sugiyama; Akira Murakami
  掲載誌名 : PHARMACEUTICS
  出版年月 : 2020年06月
• Inhibition of Amyloid beta Fibrillation by Nanoparticles Composed of Ovalbumin-derived Amphiphilic Peptides
  著者名 : Tomonori Waku; Yukako Kobayashi; Mei Wada; Taiga Hamawaki; Akihiro Handa; Michiaki Okuda; Hachiro Sugimoto; Akio Kobori; Naoki Tanaka
  掲載誌名 : CHEMISTRY LETTERS
  出版年月 : 2020年04月
• Selective cross-linking behavior of oligodeoxyribonucleotides containing 2'-O-[N-(4,5',8-trimethylpsoralen-4'-ylmethylcarbamoyl)]adenosine to mutant H-ras DNA
  著者名 : Asako Yamayoshi; Maiko Higuchi; Yui Sakai; Akio Kobori; Tsuyoshi Yamamoto; Takayuki Shibata; Akira Murakami
  掲載誌名 : NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
  出版年月 : 2020年02月
• Effect of the Hydrophilic-Hydrophobic Balance of Antigen-Loaded Peptide Nanofibers on Their Cellular Uptake, Cellular Toxicity, and Immune Stimulatory Properties
  著者名 : Tomonori Waku; Saki Nishigaki; Yuichi Kitagawa; Sayaka Koeda; Kazufumi Kawabata; Shigeru Kunugi; Akio Kobori; Naoki Tanaka
  掲載誌名 : INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  出版年月 : 2019年08月
• Photochromic DNA having fluorescent protein-inspired nucleosides
  著者名 : Akio Kobori; Taichiro Arai; Yuya Sakata; Takayuki Sugita; Asako Yamayoshi; Akira Murakami
  掲載誌名 : TETRAHEDRON LETTERS
  出版年月 : 2018年10月
• Development of a sandwich-typed assay for nucleic acids using surface-enhanced Raman scattering
  著者名 : Ryo Ota; Akio Kobori
  掲載誌名 : ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
  出版年月 : 2018年08月
• Development of photo-cross-linking oligodeoxyribonucleotides with 2 '-O-diazirine-conjugated nucleosides
  著者名 : Soichi Tatsumi; Haruka Hirose; Akio Kobori
  掲載誌名 : ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
  出版年月 : 2018年08月
• Effective Anti-miRNA Oligonucleotides Show High Releasing Rate of MicroRNA from RNA-Induced Silencing Complex
  著者名 : Jumpei Ariyoshi; Yohei Matsuyama; Akio Kobori; Akira Murakami; Hiroshi Sugiyama; Asako Yamayoshi
  掲載誌名 : NUCLEIC ACID THERAPEUTICS
  出版年月 : 2017年10月
• Inhibition Effect of Photoresponsive alpha-Haloaldehyde-conjugated Oligonucleotides on the Gene Expression in HeLa Cells Stably Expressing GFP
  著者名 : Yuta Sugihara; Yuki Nakata; Asako Yamayoshi; Akira Murakami; Akio Kobori
  掲載誌名 : CHEMISTRY LETTERS
  出版年月 : 2017年08月
• Development of Novel Photoresponsive Oligodeoxyribonucleotides with a 2 '-O-Diazirine-conjugated Adenosine for DNA Interstrand Crosslinking
  著者名 : Yuta Sugihara; Soichi Tatsumi; Akio Kobori
  掲載誌名 : CHEMISTRY LETTERS
  出版年月 : 2017年02月
• Characterization of the Releasing Profile of MicroRNA from RISC Using Anti-miRNA Oligonucleotides
  著者名 : Jumpei Ariyoshi; Nao Eimori; Akio Kobori; Akira Murakami; Hiroshi Sugiyama; Asako Yamayoshi
  掲載誌名 : CHEMISTRY LETTERS
  出版年月 : 2017年01月
• Cross-Linking Antisense Oligodeoxyribonucleotides with a Photoresponsive alpha-Chloroaldehyde Moiety for RNA Point Mutations
  著者名 : Yuta Sugihara; Yuki Nakata; Asako Yamayoshi; Akira Murakami; Akio Kobori
  掲載誌名 : JOURNAL OF ORGANIC CHEMISTRY
  出版年月 : 2016年02月
• Development of Novel Antisense Oligonucleotides for the Functional Regulation of RNA-Induced Silencing Complex (RISC) by Promoting the Release of microRNA from RISC
  著者名 : Jumpei Ariyoshi; Daiki Momokawa; Nao Eimori; Akio Kobori; Akira Murakami; Asako Yamayoshi
  掲載誌名 : BIOCONJUGATE CHEMISTRY
  出版年月 : 2015年12月
• Synthesis of Oligonucleotides Containing 4,5',8-Trimethylpsoralen at the 2'-O Position and Their Cross-Linking Properties with RNAs.
  著者名 : Akio Kobori; Asako Yamayoshi; Akira Murakami
  掲載誌名 : Current protocols in nucleic acid chemistry
  出版年月 : 2014年09月
• Photoresponsive cross-linking oligodeoxyribonucleotides with a caged alpha-chloroaldehyde group
  著者名 : Akio Kobori; Yuta Sugihara; Yuki Nakata; Asako Yamayoshi; Akira Murakami
  掲載誌名 : ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
  出版年月 : 2014年08月
• Novel Photodynamic Effect of a Psoralen-Conjugated Oligonucleotide for the Discrimination of the Methylation of Cytosine in DNA
  著者名 : Asako Yamayoshi; Yohei Matsuyama; Mikihiko Kushida; Akio Kobori; Akira Murakami
  掲載誌名 : PHOTOCHEMISTRY AND PHOTOBIOLOGY
  出版年月 : 2014年05月
• Functional regulation of RNA-induced silencing complex by photoreactive oligonucleotides
  著者名 : Yohei Matsuyama; Asako Yamayoshi; Akio Kobori; Akira Murakami
  掲載誌名 : BIOORGANIC & MEDICINAL CHEMISTRY
  出版年月 : 2014年02月
• The enzyme engineering of mutant homodimer and heterodimer of coproporphyinogen oxidase contributes to new insight into hereditary coproporphyria and harderoporphyria
  著者名 : Dao Hoang Thien Kim; Ryoko Hino; Yuka Adachi; Akio Kobori; Shigeru Taketani
  掲載誌名 : JOURNAL OF BIOCHEMISTRY
  出版年月 : 2013年12月
• Rate-adjusted cross-linking reaction by photoresponsive alpha-bromoaldehyde (PBA)-conjugated ODN
  著者名 : Akio Kobori; Yuko Nagae; Yuta Sugihara; Asako Yamayoshi; Akira Murakami
  掲載誌名 : BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  出版年月 : 2013年11月
• Dual-Fluorescent RNA Probes with an Extremely Large Stokes Shift
  著者名 : Akio Kobori; Takako Ueda; Yuya Sanada; Asako Yamayoshi; Akira Murakami
  掲載誌名 : BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
  出版年月 : 2013年05月
• Structural Insights for Design of Inhibitors against RISC Function
  著者名 : Asako Yamayoshi; Yukiko Yamada; Akio Kobori; Akira Murakami
  掲載誌名 : CHEMISTRY LETTERS
  出版年月 : 2012年12月
• RNA-based diagnosis in a multicellular specimen by whole mount in situ hybridization using an RNA-specific probe
  著者名 : Takako Ueda; Akio Kobori; Asako Yamayoshi; Hideki Yoshida; Masamitsu Yamaguchi; Akira Murakami
  掲載誌名 : BIOORGANIC & MEDICINAL CHEMISTRY
  出版年月 : 2012年10月
• Novel photoresponsive cross-linking oligodeoxyribonucleotides having a caged alpha-chloroaldehyde
  著者名 : Akio Kobori; Takemune Yamauchi; Yuko Nagae; Asako Yamayoshi; Akira Murakami
  掲載誌名 : BIOORGANIC & MEDICINAL CHEMISTRY
  出版年月 : 2012年09月
• Synthesis and Crosslinking Activity of 4-N-(4,5 ',8-Trimethylpsoralen-4 '-ylmethyl)-2 '-deoxycytidine-containing Oligodeoxyribonucleotides
  著者名 : Akio Kobori; Tomita Kohji; Yuko Nagae; Asako Yamayoshi; Akira Murakami
  掲載誌名 : CHEMISTRY LETTERS
  出版年月 : 2012年08月
• Surprising Repair Activities of Nonpolar Analogs of 8-oxoG Expose Features of Recognition and Catalysis by BaSe Excision Repair Glycosylases
  著者名 : Paige L. McKibbin; Akio Kobori; Yosuke Taniguchi; Eric T. Kool; Sheila S. David
  掲載誌名 : JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  出版年月 : 2012年01月
• Real-time Imaging of RNA Expression in Living Cells Using Bispyrene-modified RNA Probes
  著者名 : Reiko Waki; Asako Yamayoshi; Akio Kobori; Akira Murakami
  掲載誌名 : CHEMISTRY LETTERS
  出版年月 : 2011年11月
• Decoy-DNA Against Special AT-Rich Sequence Binding Protein 1 Inhibits the Growth and Invasive Ability of Human Breast Cancer
  著者名 : Asako Yamayoshi; Mariko Yasuhara; Sanjeev Galande; Akio Kobori; Akira Murakami
  掲載誌名 : OLIGONUCLEOTIDES
  出版年月 : 2011年04月
• Development of a system to sensitively and specifically visualize c-fos mRNA in living cells using bispyrene-modified RNA probes
  著者名 : Reiko Waki; Asako Yamayoshi; Akio Kobori; Akira Murakami
  掲載誌名 : CHEMICAL COMMUNICATIONS
  出版年月 : 2011年
• Nonpolar isosteres of 8-OxoG expose recognition and catalysis of DNA repair glycosylases
  著者名 : Paige L. McKibbin; Akio Kobori; Yosuke Taniguchi; Eric T. Kool; Sheila S. David
  掲載誌名 : ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
  出版年月 : 2010年08月
• Specific Regulation of Point-Mutated K-ras-Immortalized Cell Proliferation by a Photodynamic Antisense Strategy
  著者名 : Maiko Higuchi; Asako Yamayoshi; Kiyoko Kato; Akio Kobori; Norio Wake; Akira Murakami
  掲載誌名 : OLIGONUCLEOTIDES
  出版年月 : 2010年02月
• Sequence selective formation of 1,N-6-ethenoadenine in DNA by furan-conjugated probe
  著者名 : Akio Kobori; Jumpei Morita; Masato Ikeda; Asako Yamayoshi; Akira Murakami
  掲載誌名 : BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  出版年月 : 2009年07月
• Synthesis and Photoinduced Cross-linking Reactions of 4,5 ',8-Trimethylpsoralen-incorporated Oligodeoxyribonucleotide
  著者名 : Akio Kobori; Kazutaka Takaya; Maiko Higuchi; Asako Yamayoshi; Akira Murakami
  掲載誌名 : CHEMISTRY LETTERS
  出版年月 : 2009年03月
• Synthesis of antisense oligonucleotides containing 2 '-O-psoralenylmethoxyalkyl adenosine for photodynamic regulation of point mutations in RNA
  著者名 : Maiko Higuchi; Akio Kobori; Asako Yamayoshi; Akira Murakami
  掲載誌名 : BIOORGANIC & MEDICINAL CHEMISTRY
  出版年月 : 2009年01月
• Development of peptide-oligonucleotide conjugates for regulation of small RNA function.
  著者名 : Asako Yamayoshi; Daiki Momokawa; Akio Kobori; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2009年
• Real-time monitoring of mRNAs with fluorescence-modified RNA probes in living cells.
  著者名 : Reiko Waki; Takako Ueda; Asako Yamayoshi; Akio Kobori; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2009年
• Dimer of 2,7-diamino-1,8-naphthyridine for the detection of mismatches formed by pyrimidine nucleotide bases
  著者名 : Akio Kobori; Kazuhiko Nakatani
  掲載誌名 : BIOORGANIC & MEDICINAL CHEMISTRY
  出版年月 : 2008年12月
• Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker
  著者名 : Akihiro Ohkubo; Rintaro Kasuya; Katsufumi Aoki; Akio Kobori; Haruhiko Taguchi; Kohji Seio; Mitsuo Sekine
  掲載誌名 : BIOORGANIC & MEDICINAL CHEMISTRY
  出版年月 : 2008年05月
• Microarray-based label-free detection of RNA using bispyrene-modified 2 '-O-methyl oligoribonucleotide as capture and detection probe
  著者名 : Takashi Sakamoto; Akio Kobori; Akira Murakami
  掲載誌名 : BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  出版年月 : 2008年04月
• Naphthyridine-tethered oligodeoxyribonucleotides: Dye/DNA conjugates for homogeneous SNPs assays
  著者名 : Akio Kobori; Takashi Mori; Makoto Ubayashi; Akira Murakami
  掲載誌名 : CHEMISTRY LETTERS
  出版年月 : 2008年03月
• Signal detection scheme for MB-OFDM through fractional sampling
  著者名 : Akio Kobori; Yohei Kato; Yukitoshi Sanada
  掲載誌名 : 2008 3RD INTERNATIONAL CONFERENCE ON COGNITIVE RADIO ORIENTED WIRELESS NETWORKS AND COMMUNICATIONS
  出版年月 : 2008年
• Sequence-selective fluorophore formation by furan-conjugated oligodeoxyribonucleotides.
  著者名 : Akio Kobori; Junpei Morita; Masato Ikeda; Asako Yamayoshi; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2008年
• Photodynamic antisense regulation of mRNA having a point mutation with psoralen-conjugated oligonucleotide.
  著者名 : Maiko Higuchi; Asako Yamayoshi; Akio Kobori; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2008年
• Novel psoralen-conjugated antisense oligonucleotides having high photocross-linking efficiency
  著者名 : Maiko Higuchi; Asako Yamayoshi; Akio Kobori; Akira Murakami
  掲載誌名 : ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
  出版年月 : 2007年08月
• BIOL 251-Syntheses and cross-linking activities of furan-conjugated oligodeoxynucleotides
  著者名 : Akio Kobori; Takashi Kobuchi; Masato Ikeda; Akira Murakami
  掲載誌名 : ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
  出版年月 : 2007年08月
• BIOL 95-Synthesis and fluorescence properties of DANP-conjugated DNA probes for SNPs detection
  著者名 : Akio Kobori; Takashi Mori; Asako Yamayoshi; Akira Murakami
  掲載誌名 : ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
  出版年月 : 2007年08月
• Analysis of mismatched DNA by mismatch binding ligand (MBL)-Sepharose affinity chromatography
  著者名 : Yuki Goto; Hitoshi Suda; Akio Kobori; Kazuhiko Nakatani
  掲載誌名 : ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  出版年月 : 2007年07月
• Detection of L-DNA-tagged PCR products by surface plasmon resonance imaging
  著者名 : Gosuke Hayashi; Masaki Hagihara; Akio Kobori; Kazuhiko Nakatani
  掲載誌名 : CHEMBIOCHEM
  出版年月 : 2007年01月
• Allele specific C-bulge probes with one unique fluorescent molecule discriminate the single nucleotide polymorphism in DNA
  著者名 : Fumie Takei; Hitoshi Suda; Masaki Hagihara; Jinhua Zhang; Akio Kobori; Kazuhiko Nakatani
  掲載誌名 : CHEMISTRY-A EUROPEAN JOURNAL
  出版年月 : 2007年
• Selective photo-cross-linking of 2 '-O-psoralen-conjugated oligonucleotide with RNAs having point mutations
  著者名 : Maiko Higuchi; Asako Yamayoshi; Takasei Yamaguchi; Reiko Iwase; Tetsuji Yamaoka; Akio Kobori; Akira Murakami
  掲載誌名 : NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
  出版年月 : 2007年
• Gene regulation by decoy approach (II): Development of photo-cross-linked oligonucleotides duplex as a decoy DNA for estrogen receptor.
  著者名 : Asako Yamayoshi; Noriko Shimazu; Maiko Higuchi; Akio Kobori; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2007年
• Synthesis of naphthyridine-conjugated DNA probes and their application to SNPs typing.
  著者名 : Akio Kobori; Takashi Mori; Asako Yamayoshi; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2007年
• Selective regulation of mutant K-ras mRNA expression by photo-cross-linking antisense oligonucleotide.
  著者名 : Maiko Higuchi; Asako Yamayoshi; Akio Kobori; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2007年
• Homogeneous fluorescence assays for RNA diagnosis by pyrene-conjugated 2 '-O-methyloligoribonucleotides
  著者名 : Takashi Sakamoto; Akio Kobori; Masako Shigezawa; Yasutaka Amitani; Maiko Higuchi; Akira Murakami
  掲載誌名 : NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
  出版年月 : 2007年
• Conformational studies of 4-N-carbamoyldeoxycytidine derivatives and synthesis and hybridization properties of oligodeoxyribonucleotides incorporating these modified bases
  著者名 : Kenichi Miyata; Akio Kobori; Ryuji Tamamushi; Akihiro Ohkubo; Haruhiko Taguchi; Kohji Seio; Mitsuo Sekine
  掲載誌名 : EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
  出版年月 : 2006年08月
• Evaluation of mismatch-binding ligands as inhibitors for Rev-RRE interaction
  著者名 : Kazuhiko Nakatani; Souta Horie; Yuki Goto; Akio Kobori; Shinya Hagihara
  掲載誌名 : BIOORGANIC & MEDICINAL CHEMISTRY
  出版年月 : 2006年08月
• Relationship between chemical structures of galactose-modified polycation carriers and their transfection efficiency
  著者名 : Chiaki Kondo; Tomoko Hashimoto; Akio Kobori; Akira Murakami; Tetsuji Yamaoka
  掲載誌名 : Polymer Preprints, Japan
  出版年月 : 2006年
• Effects of carrier properties on expression efficiency after microinjection
  著者名 : Tomoko Hashimoto; Takeshi Nagasaki; Akio Kobori; Akira Murakami; Tetsuji Yamaoka
  掲載誌名 : Polymer Preprints, Japan
  出版年月 : 2006年
• Intracellular behavior and transcription efficiency of the polyplexes composed of micelle-type cationic carriers
  著者名 : Yumiko Kobayashi; Tomoko Hashimoto; Akio Kobori; Akira Murakami; Testuji Yamaoka
  掲載誌名 : Polymer Preprints, Japan
  出版年月 : 2006年
• Synthesis and cross-linking activities of oligodeoxynucleotides containing a 4-oxoalkenal group.
  著者名 : Akio Kobori; Takashi Kobuchi; Masato Ikeda; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2006年
• Solid-phase detection of RNA using bispyrene-modified RNA probe.
  著者名 : Takashi Sakamoto; Akio Kobori; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2006年
• Properties of novel antisense oligonucleotides containing 2'-O-modified adenosine with a photo-reactive group.
  著者名 : Maiko Higuchi; Takashi Sakamoto; Akio Kobori; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2006年
• Various properties of polymeric carriers improved the transfection efficiency.
  著者名 : Tomoko Hashimoto; Atsushi Mahara; Akio Kobori; Akira Murakami; Tetsuji Yamaoka
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2006年
• N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA.
  著者名 : Hitoshi Suda; Akio Kobori; Jinhua Zhang; Gosuke Hayashi; Kazuhiko Nakatani
  掲載誌名 : Bioorganic & medicinal chemistry
  出版年月 : 2005年07月
• Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats.
  著者名 : Kazuhiko Nakatani; Shinya Hagihara; Yuki Goto; Akio Kobori; Masaki Hagihara; Gosuke Hayashi; Motoki Kyo; Makoto Nomura; Masaki Mishima; Chojiro Kojima
  掲載誌名 : Nature chemical biology
  出版年月 : 2005年06月
• A new ligand binding to G-G mismatch having improved thermal and alkaline stability.
  著者名 : Tao Peng; Takashi Murase; Yuki Goto; Akio Kobori; Kazuhiko Nakatani
  掲載誌名 : Bioorganic & medicinal chemistry letters
  出版年月 : 2005年01月
• Development of the cell analysis chip (II)
  著者名 : Tatsuya Munaka; Masaki Kanai; Hirohisa Abe; Hiroaki Nakanishi; Takashi Sakamoto; Akio Kobori; Tetsuji Yamaoka; Shuichi Shoji; Akira Murakami
  掲載誌名 : Polymer Preprints, Japan
  出版年月 : 2005年
• Gene transfer with cationic/hydrophobic amphiphilc micelles
  著者名 : Tomoko Hashimoto; Yumiko Kobayashi; Osamu Mazda; Akio Kobori; Akira Murakami; Tetsuji Yamaoka
  掲載誌名 : Polymer Preprints, Japan
  出版年月 : 2005年
• Synthesis of antisense oligonucleotides containing a photocleavable protecting group on a guanine base and their photoinduced duplex formation
  著者名 : Reiko Iwase; Udai Fukui; Akio Kobori; Tetsuji Yamaoka; Akira Murakami
  掲載誌名 : Polymer Preprints, Japan
  出版年月 : 2005年
• Development of new photo-sensitive antisense oligonucleotides(II) Synthesis and properties of 2'-psoralen-conjugated oligonucleotides
  著者名 : Maiko Higuchi; Akio Kobori; Reiko Iwase; Tetsuji Yamaoka; Akira Murakami
  掲載誌名 : Polymer Preprints, Japan
  出版年月 : 2005年
• Gene transfer on biodegradable porous scaffolds for tissue engineering
  著者名 : Tatsuya Kitagawa; Akio Kobori; Akira Murakami; Tetsuji Yamaoka
  掲載誌名 : Polymer Preprints, Japan
  出版年月 : 2005年
• Soft tissue regeneration using novel biodegradable hydrogel /HAp composite materials
  著者名 : Yusuke Nakamura; Akio Kobori; Akira Murakami; Tetsuji Yamaoka
  掲載誌名 : Polymer Preprints, Japan
  出版年月 : 2005年
• Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA.
  著者名 : Kazuhiko Nakatani; Shinya Hagihara; Yuki Goto; Akio Kobori; Masaki Hagihara; Gosuke Hayashi; Motoki Kyo; Makoto Nomura; Masaki Mishima; Chojiro Kojima
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2005年
• Synthesis of antisense oligonucleotides containing a photocleavable protecting group on a guanine base and their photoinduced duplex formation.
  著者名 : Reiko Iwase; Udai Fukui; Akio Kobori; Tetsuji Yamaoka; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2005年
• Luminescence anisotropy-based detection of nucleic acids and proteins using long-lifetime Ru(II) complex as a luminescent label.
  著者名 : Takashi Sakamoto; Atsushi Mahara; Kobori Akio; Tetsuji Yamaoka; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2005年
• Synthesis and properties of photo-reactive antisense oligonucleotides containing 2'-O-psoralen-conjugated adenosine.
  著者名 : Maiko Higuchi; Asako Yamayoshi; Akio Kobori; Tetsuji Yamaoka; Akira Murakami
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2005年
• The destabilization of polyplexes facilitates intranuclear transcription efficiency.
  著者名 : Tomoko Hashimoto; Akio Kobori; Akira Murakami; Tetsuji Yamaoka
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2005年
• [Development of new technologies directed toward superfine gene analysis].
  著者名 : Mitsuo Sekine; Akihiro Ohkubo; Itaru Okamoto; Akio Kobori; Kohji Seio
  掲載誌名 : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
  出版年月 : 2004年12月
• 2-Ureidoquinoline: a useful molecular element for stabilizing single cytosine and thymine bulges.
  著者名 : Akio Kobori; Takashi Murase; Hitoshi Suda; Isao Saito; Kazuhiko Nakatani
  掲載誌名 : Bioorganic & medicinal chemistry letters
  出版年月 : 2004年07月
• The binding of guanine-guanine mismatched DNA to naphthyridine dimer immobilized sensor surfaces: kinetic aspects.
  著者名 : Kazuhiko Nakatani; Akio Kobori; Hiroyuki Kumasawa; Yuki Goto; Isao Saito
  掲載誌名 : Bioorganic & medicinal chemistry
  出版年月 : 2004年06月
• Highly sensitive detection of GG mismatched DNA by surfaces immobilized naphthyridine dimer through poly(ethylene oxide) linkers.
  著者名 : Kazuhiko Nakatani; Akio Kobori; Hiroyuki Kumasawa; Isao Saito
  掲載誌名 : Bioorganic & medicinal chemistry letters
  出版年月 : 2004年03月
• The SPR sensor detecting cytosine[bond]cytosine mismatches.
  著者名 : Akio Kobori; Souta Horie; Hitoshi Suda; Isao Saito; Kazuhiko Nakatani
  掲載誌名 : Journal of the American Chemical Society
  出版年月 : 2004年01月
• Detection of guanine-adenine mismatches by surface plasmon resonance sensor carrying naphthyridine-azaquinolone hybrid on the surface.
  著者名 : Shinya Hagihara; Hiroyuki Kumasawa; Yuki Goto; Gosuke Hayashi; Akio Kobori; Isao Saito; Kazuhiko Nakatani
  掲載誌名 : Nucleic acids research
  出版年月 : 2004年
• Separation of mismatched DNA by using the affinity column immobilizing mismatch-binding ligands.
  著者名 : Yuki Goto; Akio Kobori; Hitoshi Suda; Kazuhiko Nakatani
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2004年
• SPR fingerprinting of mismatched base pair.
  著者名 : Akio Kobori; Tao Peng; Gosuke Hayashi; Kazuhiko Nakatani
  掲載誌名 : Nucleic acids symposium series (2004)
  出版年月 : 2004年
• Detection of the C-C mismatched base pair by small ligands.
  著者名 : Akio Kobori; Hitoshi Suda; Kazuhiko Nakatani; Isao Saito
  掲載誌名 : Nucleic acids research. Supplement (2001)
  出版年月 : 2003年
• The binding of naphthyridine tetramer to guanine-rich sequences.
  著者名 : Yuki Goto; Shinya Hagihara; Akio Kobori; Kazuhiko Nakatani; Isao Saito
  掲載誌名 : Nucleic acids research. Supplement (2001)
  出版年月 : 2003年
• 2,6-Diaminonaphthyridine derivatives bind to a single nucleotide bulge in DNA.
  著者名 : Hitoshi Suda; Shinya Hagihara; Akio Kobori; Kazuhiko Nakatani; Isao Saito
  掲載誌名 : Nucleic acids research. Supplement (2001)
  出版年月 : 2003年
• A new method for the synthesis of oligodeoxyribonucleotides containing 4-N-alkoxycarbonyldeoxycytidine derivatives and their hybridization properties.
  著者名 : Akio Kobori; Kenichi Miyata; Masatoshi Ushioda; Kohji Seio; Mitsuo Sekine
  掲載誌名 : The Journal of organic chemistry
  出版年月 : 2002年01月
• A New Silyl Ether-Type Linker Useful for the Automated Synthesis of Oligonucleotides Having Base-Labile Protective Groups
  著者名 : KOBORI Akio; MIYATA Kenichi; USHIODA Masatoshi; SEIO Kohji; SEKINE Mitsuo
  掲載誌名 : Chemistry letters
  出版年月 : 2002年01月
• Hybridization ability and base pair geometry of modified deoxycytidine derivatives having a 4-N-carbamoyl group.
  著者名 : Kenichi Miyata; Akio Kobori; Kohji Seio; Mitsuo Sekine
  掲載誌名 : Nucleic acids research. Supplement (2001)
  出版年月 : 2002年
• Binding analysis between naphthyridine dimers and GG mismatch DNA.
  著者名 : Akio Kobori; Hiroyuki Kumasawa; Kazuhiko Nakatani; Isao Saito
  掲載誌名 : Nucleic acids research. Supplement (2001)
  出版年月 : 2002年

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