KOBORI Akio

FacultyMolecular Chemistry and Engineering
PositionProfessor
Last Updated :2021/09/16

Profile

Degree

  • 1999/03
  • 2002/03

Campus Career

  • 2004/10-2007/03, Kyoto Institute of Technology, Research Associate
  • 2007/04-2009/02, Kyoto Institute of Technology, Assistant Professor
  • 2009/03-2019/01, Kyoto Institute of Technology, Associate Professor
  • 2019/02-, Kyoto Institute of Technology, Professor
  • Homepage

    Educational Activities

    Classes

    • Biochemistry Ⅲ
    • Functional Molecular Chemistry Ⅰ
    • Molecular Design for Bioregulation
    • Biomolecular Design

    Syllabus

    Display

    Research Activities

    Research Field

    Papers

    • Synthesis of Oligonucleotides Containing 4,5',8-Trimethylpsoralen at the 2'-O Position and Their Cross-Linking Properties with RNAs
      Author : Akio Kobori, Asako Yamayoshi, Akira Murakami
      Journal : Current Protocols in Nucleic Acid Chemistry
      Publication Date : 2014/09
      Volume,Number,Page : 5.15.1
    • Novel Photodynamic Effect of a Psoralen-Conjugated Oligonucleotide for the Discrimination of the Methylation of Cytosine in DNA
      Author : Asako Yamayoshi, Yohei Matsuyama, Akio Kobori, Mikihiko Kushida, Akira Murakami
      Journal : Photochemistry and Photobiology
      Publication Date : 2014/06
      Volume,Number,Page : 90: 716?722
    • Functional regulation of RNA-induced silencing complex by photoreactive oligonucleotides
      Author : Yohei Matsuyama, Asako Yamayoshi, 小堀 哲生, Akira Murakami
      Journal : Bioorganic & Medicinal Chemistry
      Publication Date : 2013/12
      Volume,Number,Page : 22 (2014) 1003?1007
    • The enzyme engineering of mutant homodimer and heterodimer of coproporphyinogen oxidase contributes to new insight into hereditary coproporphyria and harderoporphyria
      Author : Dao Hoang, Thien Kim, Ryoko Hino, Yuka Adachi, Akio Kobori, Shigeru Taketani
      Journal : The journal of biochemistry
      Publication Date : 2013/09
      Volume,Number,Page : 154,6,551-559
    • Naphthyridine-tethered Oligonucleotides: Dye/DNA Conjugates for Homogeneous SNPs Assays
      Author : Akio Kobori, Takashi Mori, Makoto Ubayashi, Akira Murakami
      Journal : Chemistry Letters
      Publication Date : 2008/02
      Volume,Number,Page : 37, 3, 354-355
    • Homogeneous fluorescence assays for RNA-diagnosis by pyrene-conjugated 2’-O-methyl- oligoribonucleotides.
      Author : Takashi Sakamoto,, Masako Shigesawa, Yasutaka Amitani, Maiko Higuchi, Akira Murakami, Akio Kobori
      Journal : Nucleosides, Nucleotides, & Nucleic Acids
      Publication Date : 2007/12
      Volume,Number,Page : 26, 1659-1664
    • Allele Specific C-Bulge Probes with One Unique Fluorescent Molecule Discriminate the Single Nucleotide Polymorphism in DNA
      Author : F. Takei, H. Suda, J. Zhang, 小堀哲生, K. Nakatani
      Journal : Chem. Eur. J.
      Publication Date : 2007/05
      Volume,Number,Page : 13, 4452-4457
    • Selective Photo-Cross-Linking of 2'-O-Psoralen-Conjugated Oligonucleotide with RNAs Having Point Mutations.
      Author : Maiko Higuchi, Asako Yamayoshi, T. Yamaguchi, R. Iwase, Akio Kobori, T. Yamaoka, Akira Murakami
      Journal : Nucleosides Nucleotides Nucleic Acids
      Publication Date : 2007/03
      Volume,Number,Page : 26, 277-290
    • Detection of L-DNA-tagged PCR products by surface plasmon resonance imaging
      Author : Gosuke Hayashi, M. Hagihara, Akio Kobori, Kazuhiko Nakatani
      Journal : Chembiochem
      Publication Date : 2007/01
      Volume,Number,Page : 22, 169-171
    • Evaluation of mismatch-binding ligands as inhibitors for Rev-RRE interaction
      Author : K. Nakatani, S. Horie, Y. Goto, A. Kobori, S. Hagihara
      Journal : Bioorg. Med. Chem.
      Publication Date : 2006/08
      Volume,Number,Page : 14, 5384-5388
    • Conformational studies of 4-N-carbamoyldeoxycytidine derivatives and synthesis and hybridization properties of oligodeoxyribonucleotides incorporating these modified bases
      Author : K. Miyata, A. Kobori, R. Tamamushi, A. Ohkubo, H. Taguchi, K. Seio, M. Sekine
      Journal : Eur. J. Org. Chem.
      Publication Date : 2006/04
      Volume,Number,Page : 16, 3626-3637
    • Synthesis of antisense oligonucleotides containing a photocleavable protecting group on a guanine base and their photoinduced duplex formation
      Author : Reiko Iwase, Udai Fukui, Akio Kobori, Tetsuji Yamaoka, and Akira Murakami
      Journal : Nucleic Acids Symp Ser
      Publication Date : 2005/11
      Volume,Number,Page : 49, 151-152
    • Luminescence anisotropy-based detection of nucleic acids and proteins using long-lifetime Ru(II) complex as a luminescent label
      Author : Takashi Sakamoto, Atsushi Mahara, Kobori Akio, Tetsuji Yamaoka, and Akira Murakami
      Journal : Nucleic Acids Symp Ser
      Publication Date : 2005/11
      Volume,Number,Page : 49, 203-204
    • The destabilization of polyplexes facilitates intranuclear transcription efficiency
      Author : Tomoko Hashimoto, Akio Kobori, Akira Murakami, and Tetsuji Yamaoka
      Journal : Nucleic Acids Symp Ser
      Publication Date : 2005/11
      Volume,Number,Page : 49, 365-366
    • Solution structure of a small-molecular ligand complexed with CAG trinucleotide repeat DNA
      Author : Kazuhiko Nakatani, Shinya Hagihara, Yuki Goto, Akio Kobori, Masaki Hagihara, Gosuke Hayashi, Motoki Kyo, Makoto Nomura, Masaki Mishima, and Chojiro Kojima
      Journal : Nucleic Acids Symposium Series
      Publication Date : 2005/11
      Volume,Number,Page : 2005,49,49-50
    • Synthesis and properties of photo-reactive antisense oligonucleotides containing 2'-O-psoralen-conjugated adenosine
      Author : Maiko Higuchi, Asako Yamayoshi, Akio Kobori, Tetsuji Yamaoka, and Akira Murakami
      Journal : Nucleic Acids Symp Ser
      Publication Date : 2005/11
      Volume,Number,Page : 49, 331-332
    • N,N'-Bis(3^aminopropyl-2,7-diaminonaphthyridine stabilized a single pyrimidine bulge in duplex DNA.
      Author : Hitoshi Suda, Akio Kobori, Jinhua Zhang, Gosuke Hayashi and Kazuhiko Nakatani
      Journal : Bioorg. Med. Chem.
      Publication Date : 2005/07
      Volume,Number,Page : 13,(14), 4507-4512.
    • Small-molecule ligand induces nucleotide flipping in(CAG)n trinucleotide repeats
      Author : Kazuhiko, Nakatani; Shinya, Hagihara; Yuki, Goto; Akio, Kobori; Masaki, Hagihara; Gosuke, Hayashi; Motoki, Kyo; Makoto, Nomura; Masaki, Mishima; Chojiro, Kojima.
      Journal : Nature Chemical Biology
      Publication Date : 2005/00
      Volume,Number,Page : in press
    • A new ligand binding to G?G mismatch having improved thermal and alkaline stability
      Author : Tao, Peng; Takashi, Murase; Yuki, Goto; Akio, Kobori; Kazuhiko, Nakatani.
      Journal : Bioorg. Med. Chem. Lett.
      Publication Date : 2005/00
      Volume,Number,Page : 15,259-262
    • SPR fingerprinting of mismatched base pair
      Author : Akio Kobori, Tao Peng Gosuke Hayashi, Kazuhiko Nakatani
      Journal : Nucleic Acids Res. Symposium ser.
      Publication Date : 2004/11
      Volume,Number,Page : 48, 129-130
    • 2-Ureidoquinoline : a useful molecular element for stabilizing single cytosine and thymine bulges.
      Author : Akio, Kobori; Takashi, Murase; Hitoshi, Suda; Isao, Saito; Kazuhiko, Nakatani.
      Journal : Bioorg. Med. Chem. Lett.
      Publication Date : 2004/00
      Volume,Number,Page : 14、3431-3433
    • Detection of guanine-adenine mismatches by surface plasmon resonance sensor carrying naphthyridine-azaquinolone hybrid on the surface.
      Author : Shinya, Hagihara; Hiroyuki, Kumasawa; Yuki, Goto; Gosuke, Hayashi; Akio, Kobori; Kazuhiko, Nakatani
      Journal : Nucleic Acids Res.
      Publication Date : 2004/00
      Volume,Number,Page : 32,278-286
    • Highly sensitive detection of GG mismatched DNA by surfaces immobilized naphthyridine dimer through poly(ethylene oxide) linker.
      Author : Kazuhiko, Nakatani; Akio, Kobori; Hiroyuki, Kumasawa; Isao, Saito.
      Journal : Bioorg. Med. Chem. Lett.
      Publication Date : 2004/00
      Volume,Number,Page : 14,1105-1108
    • Separation of mismatched DNA by using the affinity column immobilizing mismatch-binding ligands
      Author : Yuki Goto, Akio Kobori, Hitoshi Suda, Kazuhiko Nakatani
      Journal : Nucleic Acids Res. Symposium ser.
      Publication Date : 2004/00
      Volume,Number,Page : 48, 123-124
    • The Binding of Guanine-Guanine Mismatched DNA to Naphthyridine Dimer Immobilized Sensor Surfaces: Kinetic Aspects
      Author : Kazuhiko, Nakatani; Akio, Kobori; Hiroyuki, Kumasawa; Yuki, Goto; Isao, Saito
      Journal : Bioorg. Med. Chem.
      Publication Date : 2004/00
      Volume,Number,Page : 12,3117-3123
    • 2,6-diaminonaphthyridine derivatives bind to a single nucleotide bulge in DNA.
      Author : Hitoshi, Suda; Shinya, Hagihara; Akio, Kobori; Kazuhiko, Nakatani
      Journal : Nucleic Acids Res. Supplement
      Publication Date : 2003/00
      Volume,Number,Page : 3, 139-140
    • The binding of naphthyridine tetramer to guanine-rich sequences.
      Author : Yuki, Goto; Shinya, Hagihara; Akio, Kobori; Kazuhiko, Nakatani; Isao, Saito
      Journal : Nucleic Acids Res. Supplement
      Publication Date : 2003/00
      Volume,Number,Page : 3, 133-134
    • Detection of the C-C mismatched base pair by small ligands
      Author : Akio, Kobori; Hitoshi, Suda; Kazuhiko, Nakatani; Isao, Saito.
      Journal : Nucleic Acids Res. Supplement
      Publication Date : 2003/00
      Volume,Number,Page : 3, 131-132
    • Unique participation of unprotected internucleotidic phosphodiester residues on unexpected cleavage reaction of the Si - O bond of the diisopropylsilandiyl group used as a linker for the solid-phase synthesis of 5'-terminal guanylated oligodeoxynucleotides
      Author : Masatoshi, Ushioda; Michinori, Kadokura; Tomohisa, Moriguchi; Akio, Kobori; Morihiro, Aoyagi; Kohji, Seio; Mitsuo, Sekine.
      Journal : Helv. Chim. Acta
      Publication Date : 2002/00
      Volume,Number,Page : 85, 2930-2945
    • A New Method for the Synthesis of Oligodeoxyribonucleotides Containing 4-N-Alkoxycarbonyldeoxycytidine Derivatives and Their Hybridization Properties.
      Author : Akio, Kobori; Kenichi, Miyata; Masatoshi, Ushioda; Kohji, Seio; Mitsuo, Sekine
      Journal : J. Org. Chem.
      Publication Date : 2002/00
      Volume,Number,Page : 67, 476-485
    • Hybridization ability and base pair geometry of modified deoxycytidine derivatives having a 4-N-carbamoyl group.
      Author : 12. Kenichi Miyata, Akio Kobori, Kohji Seio, Mitsuo Sekine.
      Journal : Nucleic Acids Res. Supplement
      Publication Date : 2002/00
      Volume,Number,Page : 2, 161-162
    • A new silyl ether-type linker useful for the automated synthesis of oligonucleotides having base-labile protective groups.
      Author : Akio, Kobori; Kenichi, Miyata; Masatoshi, Ushioda; Kohji, Seio; Mitsuo, Sekine.
      Journal : Chem. Lett
      Publication Date : 2002/00
      Volume,Number,Page : 1, 16-17
    • Synthesis and hybridization ability of oligodeoxyribonucleotides incorporating N-acyldeoxycytidine derivatives.
      Author : Takeshi, Wada; Akio, Kobori; Shun-Ichi, Kawahara; Mitsuo, Sekine.
      Journal : Eur. J. Org. Chem.
      Publication Date : 2001/00
      Volume,Number,Page : 4583-4593
    • Theoretical study of the hydrogen bond energy of base pairs formed between substituted 1-methylcytosine derivatives and 9-methylguanine.
      Author : Shun-Ichi, Kawahara; Akio, Kobori; Mitsuo, Sekine; Kazunari, Taira; Tadafumi, Uchimaru.
      Journal : J. Phys. Chem. A
      Publication Date : 2001/00
      Volume,Number,Page : 105, 10596-10601
    • Ab initio molecular orbital evaluation of the hydrogen bond energy of base pairs formed between substituted 1-methylcytosine derivatives and 9-methylguanine.
      Author : Shun-ichi Kawahara, Akio Kobori, Kazunari Taira, Mitsuo Sekine, Tadafumi Uchimaru.
      Journal : Nucleic Acids Research supplement
      Publication Date : 2001/00
      Volume,Number,Page : 1, 29-30


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